Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation
Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yu …
分类： Medicinal chemistry
An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhan …
Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals
Dapeng Ju, Wei Zhang, Jiawei Yan, Haijiao Zhao, Wei Li, …
A thiazole-derived oridonin analog exhibits antitumor activity by directly and allosterically inhibiting STAT3
Xiaofei Shen 1, Lin Zhao 1, Peihao Chen, Yanqiu Gong, D …
Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover
Dianrong Li, Jie Chen, Youwei Ai, Xiaoqiong Gu, Li Li, …
Staurosporine targets the Hippo pathway to inhibit cell growth
Xueyan Ma, Peixue Li, Peihao Chen, Jinhui Li, Hongling …
A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp 3 C-H arylation
Xuekai Zhang, Gang Lu, Meng Sun, Madhu Mahankali, Yanfe …
A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity
Cheng-Yang Wu, Santhosh Satapati, Wenjun Gui, Richard M …
A hybridization-chain-reaction-based method for amplifying immunosignals
Rui Lin, Qiru Feng, Peng Li, Ping Zhou, Ruiyu Wang, Zhe …
Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice
Cheng-Yang Wu, Shih-Chia Tso, Jacinta L. Chuang, Wen-Ju …