Phase separation–based HTS identifies cobimetinib as aYAP- TEAD inhibitor that suppresses hyperactivatedYAP- induced cancer progression
The Hippo signaling pathway prevents unchecked cell gro …
分类： Medicinal chemistry
To cleave or not to cleave: a systemic evaluation of DSS versus DSSO for cross-linking mass spectrometry analysis
Cross-linking mass spectrometry is a powerful method fo …
Structure-Based Optimization of TBK1 Inhibitors
Wenxuan Sun, Yuting Xie, Qiancheng Xia, Yuanxun Wang, X …
Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction
Jun Yang, Peihao Chen, Yu Cao ,Sanduo Zheng, Xiangbing …
Unlocking the secrets to human NTCP structure
Xiangbing Qi* and Wenhui Li* Sodium taurocholate co-tra …
BAFinder: A software for unknown bile acid identification using accurate mass LC-MS/MS in positive and negative modes
Yan Ma,* Yang Cao, Xiaocui Song, Yuanying Zhang, Jing L …
Flavin-Dependent Monooxygenase-Mediated 1,2-Oxazine Construction via Meisenheimer Rearrangement in the Biosynthesis of Paeciloxazine
Daojiang Yan, Kunya Wang, Songlin Bai, Bingyu Liu, Jian …
An improved auxin-inducible degron system for fission yeast
Xiao-Ran Zhang, Lei Zhao, Fang Suo, Yadong Gao, Qingcui …
Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells
Jie Chen, Nan Liu, Yinpin Huang, Yuanxun Wang, Yuxing S …
5-IP7: a GPCR messenger mediating muscarinic control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis
Xiaozhe Zhang, Na Li, Jun Zhang, Yanshen Zhang, Xiaoli …