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Publications

Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells

2021-12-10 by admin

Jie Chen, Nan Liu, Yinpin Huang, Yuanxun Wang, Yuxing S …

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5-IP7: a GPCR messenger mediating muscarinic control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis

2021-12-10 by admin

Xiaozhe Zhang, Na Li, Jun Zhang, Yanshen Zhang, Xiaoli …

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Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

2021-12-10 by admin

Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqia …

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Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors

2021-12-13 by admin

Yang Liu, Lei Zhang, Huan Yan, Zhiqiang Wang, Guoliang …

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

2021-12-13 by admin

Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yu …

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An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

2021-12-13 by admin

Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhan …

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Visible-light-induced Nickel-catalyzed Chemoselective Cross-coupling of gem-Borazirconocene Alkanes with Aryl Halides

2021-12-10 by admin

Chao Yang, Yadong Gao, Songlin Bai, Chao Jiang,* and Xi …

Direct Synthesis of Annulated Indoles through Palladium-Catalyzed Double Alkylations

2021-12-10 by admin

Yadong Gao, Jianhua Li, Songlin Bai, Daoquan Tu, Zhiwen …

Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals

2021-12-13 by admin

Dapeng Ju, Wei Zhang, Jiawei Yan, Haijiao Zhao, Wei Li, …

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Visible-Light-Induced Nickel-Catalyzed Cross-Coupling with Alkylzirconocenes from Unactivated Alkenes

2021-12-10 by admin

Yadong Gao, Chao Yang, Songlin Bai, Xiaolei Liu, Qingcu …

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News

  • Radical Ring Expansion Catalyzed by an α-Ketoglutarate-Dependent Dioxygenase in the Biosynthesis of Tropolones
  • Cp*Ir(III)-Catalyzed Asymmetric Tandem Intramolecular Aziridination/Aza-Semipinacol Rearrangement of Alkenyl 1,4,2-Dioxazol-5-one
  • Structure-Based Optimization of TBK1 Inhibitors
  • Total synthesis of (±)-3-demethoxyerythratidinone via Tf2O-promoted cascade reaction of enaminone
  • Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
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