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An improved auxin-inducible degron system for fission yeast

2022-02-28 by admin

Xiao-Ran Zhang, Lei Zhao, Fang Suo, Yadong Gao, Qingcui …

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Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells

2021-12-10 by admin

Jie Chen, Nan Liu, Yinpin Huang, Yuanxun Wang, Yuxing S …

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5-IP7: a GPCR messenger mediating muscarinic control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis

2021-12-10 by admin

Xiaozhe Zhang, Na Li, Jun Zhang, Yanshen Zhang, Xiaoli …

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Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

2021-12-10 by admin

Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqia …

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Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors

2021-12-13 by admin

Yang Liu, Lei Zhang, Huan Yan, Zhiqiang Wang, Guoliang …

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Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

2021-12-13 by admin

Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yu …

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An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

2021-12-13 by admin

Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhan …

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Visible-light-induced Nickel-catalyzed Chemoselective Cross-coupling of gem-Borazirconocene Alkanes with Aryl Halides

2021-12-10 by admin

Chao Yang, Yadong Gao, Songlin Bai, Chao Jiang,* and Xi …

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Direct Synthesis of Annulated Indoles through Palladium-Catalyzed Double Alkylations

2021-12-10 by admin

Yadong Gao, Jianhua Li, Songlin Bai, Daoquan Tu, Zhiwen …

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Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals

2021-12-13 by admin

Dapeng Ju, Wei Zhang, Jiawei Yan, Haijiao Zhao, Wei Li, …

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News

  • Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction
  • Total Synthesis of Tetrodotoxin and 9-epiTetrodotoxin
  • Bioinspired Formal Synthesis of Pancracine via Selective Hydrogenation of Indole Derivative
  • Oxidative Coupling Approach to Sarpagine Alkaloids: Total Synthesis of (−)-Trinervine, Vellosimine, (+)-Normacusine B, and (−)-Alstomutinine C
  • Visible-light-induced Enantioselective Radical Cross-Coupling of C(sp3)–Borazirconocene
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