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Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

2021-04-28 by admin

Cheng-Yang Wu, Shih-Chia Tso, Jacinta L. Chuang, Wen-Ju …

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a hybridiza-tionchain-reaction-based method for amplifying immunosignals

2021-04-28 by admin

Rui Lin, Qiru Feng, Peng Li, Ping Zhou, Ruiyu Wang, Zhe …

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In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery

2021-04-28 by admin

Yanli Wang, Yuze Sun, Ran Cao, Dan Liu, Yuting Xie, Li …

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Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors

2021-04-28 by admin

Shih-Chia Tso, Mingliang Lou, Cheng-Yang Wu, Wen-Jun Gu …

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Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals

2021-04-28 by admin

Yaling Wu, Dingbin Tang, Na Liu, Wei Xiong, Huanwei Hua …

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News

  • Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction
  • Total Synthesis of Tetrodotoxin and 9-epiTetrodotoxin
  • Bioinspired Formal Synthesis of Pancracine via Selective Hydrogenation of Indole Derivative
  • Oxidative Coupling Approach to Sarpagine Alkaloids: Total Synthesis of (−)-Trinervine, Vellosimine, (+)-Normacusine B, and (−)-Alstomutinine C
  • Visible-light-induced Enantioselective Radical Cross-Coupling of C(sp3)–Borazirconocene
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